Related Experiment Video
Updated: Jan 18, 2026

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
Published on: December 1, 2023
Inflammation and insulin profiles in men assigned to exercise vs. usual care for prostate cancer: results from the
William A Pace1, Adam Olshen2,3, Ye Wang4
1Department of Urology, UCSF, San Francisco, CA, USA. william.pace@ucsf.edu.
Objectives:
Physical activity is associated with reduced risk of prostate cancer (PCa) progression and death; changes in insulin sensitivity and inflammation are potential mediating mechanisms. This study examined whether exercise after PCa diagnosis affects insulin-related and inflammatory biomarkers.
Methods:
The Active Surveillance Exercise (ASX) randomized controlled trial was assigned to men undergoing active surveillance for low-risk, localized PCa to a 16-week exercise intervention (home-based walking program; n = 26) or printed physical activity recommendations (control group; n = 25). Fasting blood samples were collected at baseline and after 16 weeks. Samples were analyzed for markers of insulinemia (insulin, C-peptide, adiponectin), inflammation (C-reactive protein (CRP)), and prostate-specific antigen (PSA). Biomarker changes over time and between arms were analyzed using linear mixed-effects models and intention-to-treat analysis.
Results:
22 (85%) intervention and 23 (92%) control participants, mean (SD) age of 63.6 (6.6) years, provided two blood samples. Average baseline biomarker values were within expected ranges. Analyses showed no changes within or differences in changes between intervention and control groups from baseline to 16 weeks for any biomarker (p > 0.05).
Conclusions:
We observed no changes in markers of insulinemia, inflammation, or PSA from a 16-week at-home walking intervention vs. control in individuals with low-risk PCa.
Related Concept Videos
Exercise Stress Test
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Psychoneuroimmunology: Diabetes and Cancer
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Cancer Survival Analysis

