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Related Concept Videos

Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation. 
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
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Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
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Endoscopic Procedures III: Video Capsule Endoscopy01:28

Endoscopic Procedures III: Video Capsule Endoscopy

Capsule endoscopy, or wireless or video capsule endoscopy, is a diagnostic procedure for examining the entire gastrointestinal tract. Patients swallow a capsule about the size of a vitamin tablet. The capsule is equipped with a transmitter, a battery, an LED light source, and a color video camera to capture images throughout the gastrointestinal tract. This procedure is particularly useful for diagnosing conditions such as Crohn's disease, ulcerative colitis, tumors, polyps, ulcers, unexplained...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...

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Related Experiment Video

Updated: Jul 6, 2026

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
15:49

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 16, 2013

Faecal calprotectin to monitor response to treatment escalation for endoscopic postoperative recurrence of Crohn's

Laura Gutiérrez-Rios1, Margalida Calafat2, Eva Vayreda1

  • 1Gastroenterology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Catalonia, Spain.

Gastroenterologia Y Hepatologia
|January 17, 2026
PubMed
Summary

Faecal calprotectin (FC) shows promise for monitoring endoscopic recurrence in Crohn's disease (CD) after surgery. Lower FC levels after treatment escalation can indicate endoscopic improvement, aiding clinical decisions.

Keywords:
CalprotectinCalprotectinaCrohn's diseaseEndoscopic recurrenceEnfermedad de CrohnPostoperativePostoperatorioRecurrencia endoscópica

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Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
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Related Experiment Videos

Last Updated: Jul 6, 2026

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Published on: October 16, 2013

Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation
09:42

Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation

Published on: August 26, 2014

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
07:06

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

Area of Science:

  • Gastroenterology
  • Inflammatory Bowel Disease Research
  • Clinical Monitoring

Background:

  • Crohn's disease (CD) frequently involves intestinal resection, with high rates of postoperative recurrence (POR).
  • Early intervention and monitoring are crucial for managing endoscopic POR (ePOR), but non-invasive tools are limited.
  • Faecal calprotectin (FC) is a potential non-invasive biomarker for monitoring treatment response in ePOR.

Purpose of the Study:

  • To evaluate the utility of faecal calprotectin (FC) in monitoring treatment response for endoscopic postoperative recurrence (ePOR) in Crohn's disease (CD).
  • To assess the correlation between FC levels and endoscopic healing after treatment escalation for ePOR.

Main Methods:

  • Retrospective analysis of 22 CD patients with ePOR undergoing treatment escalation.
  • Collected baseline and follow-up FC levels and ileocolonoscopic assessments.
  • Primary endpoint: endoscopic improvement defined as a decrease in Rutgeerts' endoscopic score (RES) to ≤2b.

Main Results:

  • Endoscopic improvement was observed in 68% of patients after a median follow-up of 23 months.
  • Patients with baseline FC >200 μg/g showed endoscopic improvement in 73% of cases.
  • FC levels <250 μg/g predicted endoscopic improvement with 70% sensitivity and 100% specificity in patients with baseline FC >200 μg/g.

Conclusions:

  • Faecal calprotectin (FC) demonstrates potential as a non-invasive tool for monitoring endoscopic response to treatment escalation in Crohn's disease (CD) with ePOR.
  • Further validation in larger patient cohorts is necessary to confirm FC's role in managing ePOR.