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India ink-negative and culture-negative cryptococcal meningitis in HIV-negative patients

Longda Chen1,2, Gong Chen3,4, Shasha Ye3,4

  • 1Department of Infectious Disease, The Affiliated Yangming Hospital of Ningbo University, Yuyao, China.

BMC Infectious Diseases
|January 17, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
CrAg assayCryptococcal meningitisCultureIndia ink stainMortality

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Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...

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