Related Experiment Video
Updated: Jan 19, 2026
09:31
Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
Published on: January 27, 2023
1.5K
Hemodynamically significant PDA impacts adverse outcomes in infants with BPD: a multicenter study
Qianhan Ouyang1,2, Fei Bei3, Chongbing Yan1
1Department of Neonatology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Pediatric Research
|January 17, 2026
Summary
In preterm infants with bronchopulmonary dysplasia (BPD), significant hemodynamic patent ductus arteriosus (hsPDA) is linked to pulmonary hypertension and extended need for invasive respiratory support, impacting infant outcomes.
Area of Science:
- Neonatalogy
- Pediatric Cardiology
- Respiratory Medicine
Background:
- Bronchopulmonary dysplasia (BPD) and significant hemodynamic patent ductus arteriosus (hsPDA) are prevalent complications in extremely preterm infants.
- The coexistence of BPD and hsPDA raises significant clinical concerns regarding infant prognosis.
Purpose of the Study:
- To investigate the association between hsPDA and adverse outcomes in infants diagnosed with BPD.
- To provide clinical evidence for improved management strategies in this vulnerable population.
Main Methods:
- Retrospective analysis of 781 preterm infants (<32 weeks) across three hospitals (2018-2023).
- Infants were categorized based on echocardiographic assessment into non-PDA, non-hsPDA, and hsPDA groups.
- Logistic and linear regression analyses were employed to assess the effects of hsPDA on short-term outcomes in BPD infants.
Main Results:
- In BPD infants, hsPDA was associated with increased risks of pneumonia, feeding intolerance, prolonged oxygen therapy, and pulmonary hypertension (PH).
- hsPDA independently correlated with a higher risk of neonatal PH (aOR = 7.502) and significantly longer invasive respiratory support duration (β = 6.530 days).
- Ductus arteriosus diameter >3 mm was linked to elevated risks of feeding intolerance, PH, and extrauterine growth restriction.
Conclusions:
- hsPDA is a significant independent risk factor for adverse outcomes in preterm infants with BPD.
- The findings underscore the importance of managing hsPDA to mitigate risks of PH and reduce the need for prolonged respiratory support in BPD infants.
