[Mycotoxins and redox homeostasis - toxicological challenges and intervention opportunities]

Mycotoxins are secondary metabolites produced by fungi that pose a serious threat to food and feed safety worldwide. Compounds synthesized by the fungal genera Aspergillus, Fusarium, Alternaria and Penicillium are well known to have adverse effects on plant development, human and animal health. Mycotoxins threaten ecosystem stability and reduce biodiversity. Many mycotoxins disrupt redox homeostasis in animal and human organisms. This redox imbalance is the cause of both acute toxicity and long-term severe poisoning and death. Warming increases mycotoxin production. An interdisciplinary approach to mycotoxicology is crucial for addressing this complex challenge. There is a need to develop effective detoxification strategies and quality control. Advanced biomonitoring techniques that track markers of oxidative stress can improve exposure assessment. Sustainable agriculture cannot be imagined without comprehensive mycotoxin risk management. Orv Hetil. 2026; 167(3): 80-87.