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Updated: Jan 20, 2026

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
Published on: September 19, 2018
Benzothiadiazole-Induced Lipoxygenase Pathway Activation Enhances Chardonnay Grape (Vitis vinifera L.) Resistance to
Kai Wang1, Jianfeng Wang1, Xiaoying Li1
1College of Food Science and Engineering, Gansu Agricultural University, Lanzhou 730070, China.
Abstract:
Pre harvest spraying of benzothiadiazole (BTH) induces grape disease resistance and regulates the quality of wine grapes. This study investigated the mechanism of spraying 50 mg/L BTH during the pea-size stage to regulate the metabolic pathway of grape lipoxygenase (LOX). The results indicated that BTH up-regulated the expression of VvFAD21, facilitating the conversion of saturated fatty acids into unsaturated fatty acids. Additionally, BTH treatment enhanced the expression levels of VvLOXA, VvLOXB, VvLOXC, VvHPL1, VvHPL2, VvADH1, and VvADH2, resulting in increased production of C6/C9 aldehydes and alcohols. Antibacterial assays of LOX metabolites demonstrated that 40-160 μg/mL of hexanal and E-2-hexenal significantly inhibited Botrytis cinerea, the causal agent of grape gray mold. This study clarifies the mechanisms by which BTH regulates LOX metabolism to enhance grape health and berry quality, providing a theoretical basis for its application in improving grape disease resistance and controlling berry quality.
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