Related Experiment Video

Updated: Jan 20, 2026

Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts
09:29

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Published on: August 13, 2014

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FGL1 modulates macrophage function and enhances liver repair through LAG3-TNFR1 axis

Yuzhe Wu1, Qinghua Fang2, Yanyun Chen1

  • 1Guangdong Provincial Key Laboratory of New Drug Screening & NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong-Hong Kong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China.

International Immunopharmacology
|January 18, 2026
PubMed
Summary

Fibrinogen-like protein 1 (FGL1) reduces liver inflammation by modulating macrophage function. It suppresses pro-inflammatory signals via LAG3, promoting liver repair in injury models.

Keywords:
Acute liver injuryEfferocytosisFibrinogen-like protein 1MacrophagesPhagocytosisPolarization

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