Growth Failure and Early Recurrence in Congenital Diaphragmatic Hernia: An International Cohort Study
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View abstract on PubMed
Summary
This summary is machine-generated.Growth failure (GF) in congenital diaphragmatic hernia (CDH) survivors is linked to a higher risk of early hernia recurrence. Addressing growth challenges through targeted nutrition may reduce recurrence rates in these patients.
Area Of Science
- Pediatric Surgery
- Neonatology
- Growth and Development
Background
- Growth failure (GF) is a frequent complication in congenital diaphragmatic hernia (CDH) survivors.
- The impact of growth challenges on CDH morbidity, specifically hernia recurrence, requires further clarification.
- Current CDH nutritional guidelines may need refinement regarding the relationship between growth and adverse outcomes.
Purpose Of The Study
- To investigate the association between growth failure (GF) and early recurrence in congenital diaphragmatic hernia (CDH) patients.
- To determine the prevalence and severity of GF among CDH survivors.
- To identify GF as a potential risk factor for CDH recurrence.
Main Methods
- A multicenter cohort study retrospectively analyzed prospective data from the CDH Study Group (CDHSG) registry.
- Weight-for-age Z-scores (WAZ) were calculated for CDH survivors (born 2007-2023), with GF defined as WAZ <-2.0 at discharge.
- Non-parametric tests and logistic regression were used to analyze the data.
Main Results
- Among 4,931 CDH survivors, 14.6% experienced GF.
- Hernia recurrence occurred in 3.3% of survivors, with a significantly higher rate in those with GF (6.4% vs. 2.8%, p<0.001).
- GF was associated with an 80% increased odds of early recurrence (aOR 1.8, p=0.007).
Conclusions
- Growth failure (GF) is a significant risk factor for early recurrence in congenital diaphragmatic hernia (CDH).
- Targeted nutritional interventions are crucial for potentially mitigating CDH recurrence.
- Further research should focus on center-specific practices and long-term outcomes related to nutrition and growth in CDH survivors.
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