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Updated: Jan 20, 2026
07:06
Somatic Stem cells in Tissue Repair and Regeneration
Published on: April 30, 2023
21.4K
Stem cells in organogenesis and regeneration.
Tasmia Jahin Mim1, Iftakhar Ahmad2, Salima Raiyan Basher3
1Department of Mathematics and Natural Sciences, BRAC University, Dhaka, Bangladesh.
Stem Cell Research & Therapy
|January 18, 2026
Summary
Stem cells drive organ development and tissue repair, guided by key signaling pathways. This review explores stem cell types, organogenesis, and therapeutic potential, including advanced technologies and ethical considerations.
Area of Science:
- Stem cell biology
- Developmental biology
- Regenerative medicine
Background:
- Stem cells are fundamental to organogenesis and tissue regeneration.
- Their activity is crucial for development, maintenance, and repair processes.
- Understanding stem cell roles is key to advancing regenerative therapies.
Purpose of the Study:
- To provide a comprehensive overview of stem cell types and their sources.
- To highlight the role of stem cells and signaling pathways in organogenesis.
- To discuss the translational progress and challenges of stem cell-based therapies.
Main Methods:
- Review of major stem cell types (embryonic, induced pluripotent, mesenchymal).
- Analysis of critical signaling pathways (Wnt, Notch, Hedgehog, BMP).
- Exploration of organoid models, stem cell niches, and advanced technologies (CRISPR, 3D bioprinting).
Main Results:
- Stem cells, regulated by signaling pathways, are essential for organ formation and regeneration.
- Organoids serve as valuable models for studying development and disease.
- Mesenchymal stem cells are vital for tissue repair and therapeutic applications.
Conclusions:
- Stem cell biology offers significant potential for clinical translation.
- Advanced technologies are revolutionizing stem cell research and applications.
- Future directions involve addressing safety, efficacy, and ethical considerations in stem cell therapies.
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