Related Experiment Video
Updated: Jan 20, 2026
Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
Published on: December 11, 2017
Transcatheter Aortic Valve Replacement With Self-Expanding Valves in Severe Pure Native Aortic Regurgitation-Is It
Weijing Zhang1,2,3,4,5, Xinjing Chen6, Longyan Zhang7
1Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China.
Background:
The non-coronary sinus pivot implantation (NCPI) technique has notably improved procedural success rate in transcatheter aortic valve replacement (TAVR) for cases of severe pure native aortic regurgitation (PNAR) when utilizing self-expanding transcatheter heart valves (THVs). Nonetheless, the intrinsic anchoring mechanism remains obscure.
Aims:
The aim of this study was to assess the feasibility of implementation of the NCPI method using self-expanding THVs for TAVR in severe PNAR and dilated ascending aortas (AAOs), and to elucidate the anchoring mechanism of the NCPI.
Methods:
The study consecutively enrolled patients with severe PNAR and significantly dilated AAOs, who underwent TAVR with a NCPI technique. Clinical outcomes and a composite of all-cause mortality at 30 days and 12 months were assessed. Additionally, the post-TAVR cardiac multidetector computed tomographies (MDCTs) were conducted to investigate the anchoring mechanism.
Results:
A total of 12 patients were enrolled. The median age was 77 years, and the mean Society of Thoracic Surgery (STS) risk score was 10.1%, with a mean aortic annular perimeter of 80.0 mm, a median ascending aortic diameter of 47.9 mm. Device success rates were 100%. In all patients, post-TAVR cardiac MDCT analysis revealed stable anchorage of the THV via the non-coronary side insertion and the left-coronary side compacting contact achieved by the NCPI method despite the presence of ascending aortic dilation.
Conclusions:
Preliminarily speaking, with the implementation of the NCPI method, the utilization of off-label self-expanding THVs for TAVR in severe PNAR and significantly dilated AAOs is deemed feasible. Stable anchorage of the THV was achieved using the NCPI method.
More Related Videos
05:31Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
Published on: June 8, 2022
12:17Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
Published on: May 21, 2017
Related Concept Videos
14:14Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
05:31Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
12:17Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
09:57Four-Dimensional Computed Tomography-Guided Valve Sizing for Transcatheter Pulmonary Valve Replacement
08:50Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement
05:47Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro