Fluoroscopic angles should be individualised when performing myocardial biopsies in children

Koichi Takamizawa1, Katsutoshi Nakano1,2, Hideki Doi1

  • 1Department of Pediatrics, Graduate School of Medicine, https://ror.org/022cvpj02University of Tokyo, Tokyo, Japan.

Cardiology in the Young
|January 19, 2026
PubMed

Insights

Paediatric myocardial biopsy requires precise instrument alignment due to variable ventricular septal angles. Individualized fluoroscopic guidance, informed by CT scans, can improve biopsy forceps positioning and reduce serious complications.

Area of Science:

  • Cardiology
  • Pediatric Interventional Procedures
  • Medical Imaging

Background:

  • Percutaneous myocardial biopsy carries a risk of ventricular perforation.
  • Accurate fluoroscopic orientation of biopsy forceps is crucial for safety.
  • Paediatric patients exhibit complex ventricular septal variations complicating biopsy procedures.

Purpose of the Study:

  • To investigate ventricular septal orientation variability in paediatric patients.
  • To assess the efficacy of individualized fluoroscopic guidance for myocardial biopsy in children.

Main Methods:

  • Retrospective analysis of paediatric myocardial biopsies (2019-2023).
  • Cardiac CT used to measure ventricular septal angles relative to the sagittal plane.
  • Fluoroscopic guidance with individualized angles for biopsy forceps alignment.

Main Results:

  • Analyzed 16 paediatric patients (85 biopsies total, first per patient).
  • Mean septal angle: 54.3° (range 30.0-75.0°).
  • Mean combined angle for forceps alignment: 75.6° (range 45.0-115.7°).
  • No ventricular perforations occurred.

Conclusions:

  • Significant variability exists in paediatric ventricular septal orientation.
  • Pre-procedural CT measurements enable individualized fluoroscopic angles.
  • This approach enhances biopsy forceps accuracy and may mitigate severe procedural risks.
Abstract

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