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Updated: Jan 20, 2026
Green Algae
Published on: June 13, 2025
Green Alga Enteromorpha prolifera Oligosaccharide Exerts Antiaging Effects through Targeted Modulation of Protein
Shuo Shan1,2, Weichao Chen1, Weihao Wu1
1College of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Abstract:
Aging and diabetes are intricately linked, with metabolic dysregulation playing a pivotal role in the pathophysiology of both conditions. This study investigates the therapeutic potential of Enteromorpha prolifera oligosaccharide (EPO) in mitigating aging-related metabolic decline through modulation of O-GlcNAcylation. The results demonstrate that EPO treatment significantly reduced O-GlcNAc levels, thereby attenuating ROS accumulation and alleviating cell cycle arrest to counteract aging-associated metabolic decline. Specifically, shOGA increased ROS by 77.0% and induced G2/M arrest (12.2%). These alterations were mimicked by TMG but reversed by EPO, identifying OGA as the primary driver of ROS generation and cell cycle regulation. shHCF1 decreased ROS (48.8% to 28.3%), G0/G1 (59.7%), and S phase (6.6%) but increased G2/M to 30.9%, suggesting ROS attenuation alongside G2/M arrest. Overall, this research highlights the role of EPO in regulating key cellular processes, providing new insights for the development of antiaging therapies.
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