Related Experiment Video
Updated: Jan 20, 2026
03:59
Surgical Correction for Pediatric Epiblepharon and Trichiasis
Published on: July 8, 2025
526
Correct answer to the quiz. Check your diagnosis Cellular dermatofibroma
Magdalena Justyna Kacperska-Olborska1, Bogusław Olborski2, Jerzy Ogłuszka3
1Regional Hospital of John Paul II, Belchatow, Poland.
Summary
Dermatofibroma (DF), a common skin lesion, is a benign growth of dermal oval and spindle cells. Histopathology, sometimes with immunohistochemistry, is crucial for diagnosing difficult or suspicious DF cases.
Area of Science:
- Dermatopathology
- Cutaneous Oncology
- Surgical Pathology
Background:
- Dermatofibroma (DF), also known as fibrous histiocytoma, represents approximately 3% of skin lesion specimens in dermatopathology labs.
- DF is a benign dermal proliferation of oval cells resembling histiocytes and spindle cells resembling fibroblasts.
- Clinically, DF presents as firm nodules or papules, varying from solitary to multiple lesions.
Purpose of the Study:
- To highlight the essential role of histopathology in diagnosing dermatofibroma.
- To underscore the diagnostic utility of immunohistochemical staining in challenging dermatofibroma cases.
- To provide a concise overview of dermatofibroma characteristics and diagnostic approaches.
Main Methods:
- Review of dermatopathology laboratory specimens.
- Histopathological examination of skin lesions.
- Application of immunohistochemical staining in select cases for differential diagnosis.
Main Results:
- Dermatofibroma is a frequent benign cutaneous soft-tissue lesion.
- Histopathology is confirmed as the gold standard for definitive dermatofibroma diagnosis.
- Immunohistochemistry aids in resolving diagnostic ambiguities in complex presentations.
Conclusions:
- Accurate diagnosis of dermatofibroma relies heavily on histopathological evaluation.
- Histopathology, supplemented by immunohistochemistry, is vital for managing challenging dermatofibroma cases.
- Understanding the histomorphology of dermatofibroma is key for dermatopathologists.
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