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Updated: Jan 20, 2026

Analyzing the Function of Small GTPases by Microinjection of Plasmids into Polarized Epithelial Cells
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Published on: May 31, 2011

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Desmosome Assembly Regulates Apical-Basal Polarization and Nuclear Shape in Simple Epithelial Cells

Tobuhiro Nita1, Junya Hayase1, Akira Kohda1

  • 1Department of Biochemistry, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Genes to Cells : Devoted to Molecular & Cellular Mechanisms
|January 19, 2026
PubMed
Summary

Desmosome assembly in simple epithelia involves E-cadherin and cadherin-6 recruiting plakoglobin, which then recruits other proteins for desmosome formation. Desmoplakin is crucial for cell polarity and nuclear shape.

Keywords:
MDCK cellscadherin‐6desmoplakindesmosomeepithelial cell polaritynuclear shape

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