Effect of Transcranial Direct Current Stimulation on Motor Speech in Nonfluent Primary Progressive Aphasia: A Case

Yoshihiro Ohashi1, Satoko Koganemaru2, Fumiko Oshima3

  • 1Department of Medical Welfare, Department of Speech and Hearing, Faculty of Health Sciences, Kyoto Koka Women's University, Kyoto, Japan.

Case Reports in Neurology
|January 19, 2026
PubMed
Summary

Transcranial direct current stimulation (tDCS) combined with speech and language disorder rehabilitation may improve motor speech functions in primary progressive aphasia (PPA). This N-of-1 study showed benefits for articulation and vocalization in a patient with nonfluent variant PPA.

Related Concept Videos

Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation11:11

Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation

Transcranial Alternating Current Stimulation (tACS) allows the modulation of cortical excitability in a frequency-specific fashion. Here we show a unique approach which combines online tACS with single pulse Transcranial Magnetic Stimulation (TMS) in order to "probe" cortical excitability by means of Motor Evoked Potentials.
9.6K
Transcranial Direct Current Stimulation for Online Gamers06:01

Transcranial Direct Current Stimulation for Online Gamers

We present a protocol and a feasibility study for applying transcranial direct current stimulation (tDCS) and neuroimaging assessment in online...
8.5K
Transcranial Direct Current Stimulation (tDCS) in Mice11:54

Transcranial Direct Current Stimulation (tDCS) in Mice

Transcranial direct current stimulation (tDCS) is a therapeutic technique proposed to treat psychiatric diseases. An animal model is essential for understanding the specific biological alterations evoked by tDCS. This protocol describes a tDCS mouse model that uses a chronically implanted...
15.1K
Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia10:15

Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia

We explore the use of repetitive transcranial magnetic stimulation (rTMS) to improve language abilities in patients with chronic stroke and non-fluent aphasia. After identifying a site in the right frontal gyrus for each patient that responds optimally to stimulation, we target this site during ten days of rTMS...
18.3K
Using Home-based, Remotely Supervised, Transcranial Direct Current Stimulation for Phantom Limb Pain06:13

Using Home-based, Remotely Supervised, Transcranial Direct Current Stimulation for Phantom Limb Pain

The goal of this study is to describe a protocol for the home-based delivery of remotely supervised transcranial direct current stimulation (RS-tDCS) conserving the standard procedures of in-clinic practice, including safety, reproducibility, and tolerability. The participants included will be patients with phantom limb pain...
1.8K
Neuronavigation-guided Repetitive Transcranial Magnetic Stimulation for Aphasia08:48

Neuronavigation-guided Repetitive Transcranial Magnetic Stimulation for Aphasia

This study is designed to test the hypothesis that neuronavigational system-guided transcranial magnetic stimulation has higher accuracy for targeting the intended target as demonstrated by eliciting a greater degree of virtual aphasia in healthy subjects, measured by delay in reaction time to picture...
12.8K