Related Experiment Video
Updated: Jan 20, 2026
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
Effects of mental disorders on the relationship between physical activity and bone markers among depressed patients
Sanne Houtenbos1,2, Yangyang He1,2, Andrea Block1
1Medical Sociology and Psychobiology, Department of Health and Physical Activity, University of Potsdam, 14469 Potsdam, Germany.
Objective:
Physical activity (PHYA) positively influences bone health, but this relationship might be affected by mental disorders. Aims: (1) evaluate whether mental disorders influence bone markers and (2) whether the relationship of PHYA with bone markers is influenced by mental disorders.
Methods:
A secondary data analysis of the longitudinal DEPREHA-study (Germany, 18 months, n = 208, 18-65y, ICD-10 F32.x-F33.x, collected 2015-2017) was conducted. Baseline data: sociodemographic, PHYA, depressive (BDI-II) and psychosomatic (SCL-90) symptoms; bone markers procollagen-type-1-N-propeptide (P1NP), osteocalcin (OC) and crosslaps (CTx) were analyzed. Multiple linear regressions assessed associations of depressive and psychosomatic symptoms with bone markers and moderating effects of depressive and psychosomatic symptoms on the PHYA-bone marker relationship; Mediation analyses were conducted with the PROCESS macro. All analyses were conducted in IBM SPSS (v31.0; p < 0.05).
Results:
Data from n = 44 depressed participants were eligible for analysis. Significant associations of BDI-II and SCL-90 with P1NP and OC were detected. A significant moderation of SCL-90 on the relationship of PHYA with P1NP (p < 0.05), but no mediation effect of BDI-II or SCL90 on bone markers was detected.
Conclusions:
Depressive and psychosomatic symptoms influence and may potentially moderate the relationship between PHYA and bone markers, which should be considered in further studies and therapeutic planning.
Related Concept Videos
04:33Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
08:20MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
35:03Mental Status Examination
The mental status exam is a clinical evaluation of emotional, perceptual, and cognitive functioning that spans both the fields of psychiatry and neurology. Developing skill in the psychiatric portions of the examination are important to describe salient aspects of the patient's mental state that may be observed during routine history and/or physical exam. Proficiency in the cognitive portions...
01:27Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
06:51Physical Activity Measurement in Children Accepting Table Tennis Training
01:29Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...