Both Oocyte Hyperresponse and Oocyte Vitrification Are Safe Procedures Regarding Embryo Euploidy: A Real-World Study...

Area of Science:

• Reproductive Medicine
• Embryology
• Genetics

Background:

• Ovarian hyperresponse and oocyte vitrification (OV) are common in assisted reproductive technologies.
• Concerns exist regarding potential impacts on embryo euploidy rates.

Purpose of the Study:

• To investigate if ovarian hyperresponse and oocyte vitrification (OV) are linked to increased embryo aneuploidy.
• To analyze euploidy rates in relation to oocyte yield and maturity.

Main Methods:

• Retrospective analysis of 197,629 retrieved oocytes.
• Evaluation of euploidy rate (ER), ER based on oocyte number (ERaRO), ER based on mature oocytes (ERaMII), and mature oocyte rate (MOR).
• Regression analysis to compare aneuploidy rates of fresh versus vitrified oocytes.

Main Results:

• Maximal ERaRO was observed with one retrieved oocyte (27%), decreasing with more oocytes but stabilizing around 10% from the 3rd to 36th.
• Euploidy rates were generally higher with 100% mature oocyte rate (MOR), particularly with 1-2 mature oocytes.
• Vitrified oocytes demonstrated similar aneuploidy rates to fresh oocytes after adjustment.

Conclusions:

• Ovarian hyperresponse and oocyte vitrification (OV) are safe procedures regarding embryo euploidy.
• The higher euploidy rates observed with 1-2 oocytes warrant further research into oocyte quality in these specific cycles.