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Related Experiment Video

Updated: Jan 20, 2026

Determining the Role of Maternally-Expressed Genes in Early Development with Maternal Crispants
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A Learning Health System Approach to Developing a Perinatal Safety Framework and Guide to Reduce Disparities in

Angela D Thomas1,2,3, Tamika Auguste1,3,4, Allan Fong2

  • 1MedStar Health Columbia Maryland USA.

Learning Health Systems
|January 19, 2026
PubMed
Summary

Maternal harm disproportionately impacts Black individuals. This study developed a comprehensive, patient-centered safety framework using Learning Health System principles to address disparities and improve maternal safety through full-spectrum surveillance.

Keywords:
health equitylearning health systemmaternal disparitiesmaternal safety

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Area of Science:

  • Maternal Health
  • Healthcare Quality Improvement
  • Health Equity

Background:

  • Maternal harm, including severe maternal morbidity (SMM) and mortality, disproportionately affects Black birthing individuals.
  • Systemic and provider-related factors significantly contribute to preventable maternal harm.
  • Traditional safety approaches often exclude patient voices and focus narrowly on severe events, limiting proactive interventions.

Purpose of the Study:

  • To develop a comprehensive maternal safety framework using the National Academies of Medicine's Learning Health System (LHS) principles.
  • To integrate patient-reported experiences, provider perspectives, and clinical data for a full-spectrum safety surveillance approach.
  • To create actionable recommendations for a Perinatal Safety Framework and a Perinatal Strategy Guide.

Main Methods:

  • A mixed-methods approach was employed, integrating patient-reported experiences, provider perspectives, clinical informatics, natural language processing, and chart reviews.
  • Patient cases (experiencing SMM or postpartum readmission) and controls were included.
  • An interdisciplinary expert panel synthesized findings to develop the framework and guide.

Main Results:

  • The Perinatal Maternal Safety Framework defines the maternal safety continuum with six key features, including distinct starting points (pregnancy, birth, postpartum), a broad definition of harm, and contributing/mitigating factors.
  • The Perinatal Strategy Guide provides evidence-based strategies to address structural and systemic factors impacting maternal safety.
  • The framework integrates full-spectrum safety surveillance and patient-centered reporting.

Conclusions:

  • A comprehensive, patient-centered maternal safety framework is critical for addressing health disparities.
  • Applying LHS principles offers a data-driven, equity-focused approach to improving maternal safety.
  • Implementing the Perinatal Strategy Guide requires interdisciplinary collaboration and engagement with individuals with lived experience.