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Related Concept Videos

Synthesis and Characterization of Functionalized Metal-organic Frameworks11:27

Synthesis and Characterization of Functionalized Metal-organic Frameworks

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Synthesis, activation, and characterization of intentionally designed metal-organic framework materials is challenging, especially when building blocks are incompatible or unwanted polymorphs are thermodynamically favored over desired forms. We describe how applications of solvent-assisted linker exchange, powder X-ray diffraction in capillaries and activation via supercritical CO2 drying, can address some of these...
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Determining Surface Areas and Pore Volumes of Metal-Organic Frameworks06:45

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This article describes the use of nitrogen porosimetry to characterize metal-organic frameworks, using UiO-66 as a representative material.
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Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks (MOFs)08:25

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Here, we present a protocol for active site validation of metal-organic framework catalysts by comparing stoichiometric and catalytic carbonyl-ene reactions to find out whether a reaction takes place on the inner or outer surface of metal-organic...
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A Technical Guide for Performing Spectroscopic Measurements on Metal-Organic Frameworks10:13

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Here, we use a polymer stabilizer to prepare metal-organic framework (MOF) suspensions that exhibit markedly decreased scatter in their ground-state and transient absorption spectra. With these MOF suspensions, the protocol provides various guidelines to characterize the MOFs spectroscopically to yield interpretable...
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Electric Cell-Substrate Sensing for Real-Time Evaluation of Metal-Organic Framework Toxicological Profiles04:53

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The following study evaluates the toxicological profile of a selected metal-organic framework utilizing electric cell-substrate impedance sensing (ECIS), a real-time, high-throughput screening technique.
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Ex situ magnetic surveys can directly provide bulk and local information on a magnetic electrode to reveal its charge storage mechanism step by step. Herein, electron spin resonance (ESR) and magnetic susceptibility are demonstrated to monitor the evaluation of paramagnetic species and their concentration in a redox-active metal-organic framework...
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Updated: Jan 20, 2026

Synthesis and Characterization of Functionalized Metal-organic Frameworks
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Metal-organic frameworks in pharmaceutical research.

Zimeng Tao1, Kun Hu1, Baoxi Zhang1

  • 1Beijing Key Laboratory of Innovative Drug Discovery and Polymorphic Research for Cerebrovascular Diseases, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.

Pharmaceutical Science Advances
|January 19, 2026
PubMed
Summary
This summary is machine-generated.

Metal-organic frameworks (MOFs) offer advanced drug delivery solutions due to high loading capacity and controlled release. Further research is needed to address scalability and biosafety for clinical use.

Keywords:
Drug delivery systemDrugsMetal-organic frameworkStructural analysis

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Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
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Area of Science:

  • Materials Science
  • Nanotechnology
  • Pharmaceutical Sciences

Background:

  • Metal-organic frameworks (MOFs) are versatile porous materials with significant pharmaceutical potential.
  • MOFs offer unique advantages for drug delivery systems.

Purpose of the Study:

  • To provide a comprehensive review of MOF synthesis, characterization, and biomedical applications.
  • To highlight MOFs' potential in drug delivery, biosensing, and therapeutic platforms.
  • To identify challenges and future directions for clinical translation of MOFs.

Main Methods:

  • Review of synthesis strategies including hydrothermal, electrochemical, and microwave methods.
  • Discussion of characterization techniques such as X-ray diffraction (XRD), SEM, and BET analysis.
  • Exploration of diverse biomedical applications and advanced MOF systems.

Main Results:

  • MOFs exhibit high drug loading capacity, biocompatibility, and controlled release capabilities.
  • Applications include improved drug solubility/stability, pulmonary delivery, biosensing, and antimicrobial therapy.
  • Advanced MOFs demonstrate stimuli-responsiveness and self-propulsion for targeted delivery.

Conclusions:

  • MOFs show great promise for next-generation drug delivery systems and therapeutic platforms.
  • Addressing challenges in scalability, reproducibility, and biosafety is crucial for clinical translation.
  • This review bridges MOF materials science with pharmaceutical applications for rational design.