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Related Experiment Video

Updated: Jan 20, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Contemporary 0.55 T MRI to visualize interstitial lung disease - An exploratory study.

Nadine Bayerl1, Claudius S Mathy1, Christina Bergmann2,3

  • 1Institute of Radiology, Friedrich-Alexander-Universität Erlangen-Nürnberg and University Hospital Erlangen, Maximiliansplatz 3, Erlangen 91054, Germany.

European Journal of Radiology Open
|January 19, 2026
PubMed
Summary
This summary is machine-generated.

Low-field MRI shows promise for assessing interstitial lung disease (ILD) extent without radiation. While it accurately measures overall ILD, further refinement is needed for specific features like ground-glass opacity and reticulation.

Keywords:
Computed tomography, X-RayDiagnostic imagingInterstitial lung diseasesMagnetic resonance imagingScleroderma, Systemic

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Area of Science:

  • Radiology
  • Pulmonary Medicine
  • Medical Imaging

Background:

  • Interstitial lung disease (ILD) diagnosis and monitoring often rely on high-resolution computed tomography (HRCT).
  • HRCT involves ionizing radiation, prompting the search for alternative imaging modalities.
  • Low-field magnetic resonance imaging (MRI) offers a radiation-free approach to visualize lung structures.

Purpose of the Study:

  • To assess the feasibility of contemporary 0.55 Tesla (T) MRI for visualizing interstitial lung disease (ILD).
  • To compare the diagnostic performance of 0.55T MRI against high-resolution computed tomography (HRCT) in patients with rheumatologic ILD.
  • To evaluate MRI's ability to quantify overall disease extent, ground-glass opacity (GGO), and reticulation.

Main Methods:

  • Thirty participants with rheumatologic ILD underwent both HRCT and 0.55T MRI within 31 days.
  • MRI protocols included proton-density-weighted and T2-weighted sequences.
  • Three blinded radiologists independently assessed disease features using semi-quantitative scoring, with data analyzed via Wilcoxon signed-rank and Bland-Altman tests.

Main Results:

  • No statistically significant difference was found in the overall extent of ILD between 0.55T MRI and HRCT (22.5% vs. 24.5%).
  • MRI significantly overestimated ground-glass opacity (GGO) (13.1% vs. 9.7%) and underestimated reticulation (8.1% vs. 11.4%) compared to HRCT.
  • Excellent interobserver agreement was observed for both modalities (MRI ICC = 0.94; HRCT ICC = 0.97).

Conclusions:

  • Contemporary 0.55T MRI is feasible for assessing overall ILD extent, showing no significant difference compared to HRCT.
  • Despite limitations in quantifying GGO and reticulation, 0.55T MRI shows potential as a radiation-free tool for gross ILD burden assessment.
  • Further technical advancements are warranted before 0.55T MRI can be routinely implemented in clinical practice for ILD evaluation.