Related Experiment Video

Updated: Jan 20, 2026

Targeted DNA Methylation Analysis by Next-generation Sequencing
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Targeted DNA Methylation Analysis by Next-generation Sequencing

Published on: February 24, 2015

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End-repair causes methylation underestimation in cell-free DNA sequencing libraries

Tobin E Groth1, Andrew A Mishin1, Varsha Rao1

  • 1Claret Bioscience LLC, 100 Enterprise Way, Suite A102, Scotts Valley, CA, 95066, USA.

The Journal of Liquid Biopsy
|January 19, 2026
PubMed

Keywords:
Cell-free DNA (cfDNA)Double-stranded DNA (dsDNA) library preparationEnd-repairFragmentomicsMethylation sequencingNucleosome positioningSingle-stranded DNA (ssDNA) library preparationTissue of origin (TOO)

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