Cerebrospinal fluid metabolomic signatures in paediatric MOGAD and POMS
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View abstract on PubMed
Summary
This summary is machine-generated.Metabolomic and lipidomic analyses of cerebrospinal fluid (CSF) can help differentiate Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) from paediatric-onset multiple sclerosis (POMS). These omic analyses offer a novel diagnostic approach for early identification of demyelinating disorders in children.
Area Of Science
- Neuroscience
- Biochemistry
- Pediatric Neurology
Background
- Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) and paediatric-onset multiple sclerosis (POMS) are acquired demyelinating syndromes (ADSs) with overlapping clinical and MRI features but distinct prognoses and management strategies.
- Accurate early diagnosis of POMS is crucial for limiting disability, while differentiating it from MOGAD is essential for appropriate patient management and counseling.
- Current diagnostic biomarkers, including CSF analysis and MRI, are not always definitive, especially at disease onset, highlighting the need for novel diagnostic approaches.
Purpose Of The Study
- To investigate the utility of cerebrospinal fluid (CSF) metabolomic and lipidomic profiling for differentiating MOGAD and POMS in children.
- To identify novel biomarkers for early and accurate diagnosis of pediatric demyelinating disorders.
Main Methods
- High-sensitivity shotgun mass spectrometry was employed to analyze the CSF metabolome and lipidome.
- The study compared CSF profiles of children with MOGAD and POMS against a control group with non-demyelinating diseases.
- Analysis included 128 hydrophilic metabolites and 210 lipids, with statistical adjustments for multiple comparisons (FDR) and effect size evaluation.
Main Results
- Distinct changes in CSF metabolic concentrations were observed between MOGAD and POMS, primarily involving energy metabolism pathways.
- Specific lipidomic alterations included the accumulation of plasmalogens, phosphatidylethanolamine (PE), and cholesterol esters in MOGAD.
- POMS exhibited higher signal intensities for very-long-chain PE and triglycerides (TG), though these findings require validation in larger cohorts.
Conclusions
- CSF metabolomic and lipidomic profiling provides a valuable, fast, and reliable method for biomarker discovery in pediatric demyelinating neurological disorders.
- Broad-range omic analysis can serve as a complementary diagnostic tool to existing biomarkers for early disease identification.
- These findings support the potential of metabolomics and lipidomics in improving the differential diagnosis and management of MOGAD and POMS.
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