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Related Experiment Video

Updated: Jan 20, 2026

Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research
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Pox-AbDab: the orthopoxvirus antibody database.

Henriette L Capel1, Eric Ji Da Wang1, Benjamin H Williams1

  • 1Oxford Protein Informatics Group, Department of Statistics, University of Oxford, Oxford, United Kingdom.

Frontiers in Immunology
|January 19, 2026
PubMed
Summary

The Orthopoxvirus Antibody Database (Pox-AbDab) centralizes mpox virus antibody data. This resource aids research into orthopoxvirus therapeutics and addresses knowledge gaps for future studies.

Keywords:
antibodyantigenepitopesmpoxneutralisingsequencestructure

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Area of Science:

  • Virology
  • Immunology
  • Bioinformatics

Background:

  • Mpox (orthopoxvirus) was declared a Public Health Emergency of International Concern by the WHO in August 2024.
  • Continued research into mpox microbiology and therapeutics is crucial.
  • Existing data on orthopoxvirus-binding antibodies are fragmented.

Purpose of the Study:

  • To present the Orthopoxvirus Antibody Database (Pox-AbDab), a centralized repository for orthopoxvirus antibody data.
  • To standardize and consolidate existing knowledge on antibodies targeting viruses within the Orthopoxvirus genus.
  • To analyze the landscape of orthopoxvirus-binding antibodies and identify research gaps.

Main Methods:

  • Development of the Orthopoxvirus Antibody Database (Pox-AbDab).
  • Data curation and standardization of antibody-binding and neutralization information.
  • Exploratory analysis of antibody properties, cross-reactivity, immunodominance, immune escape, and epitope coverage.

Main Results:

  • The Pox-AbDab database provides a centralized resource for orthopoxvirus antibody data.
  • Analysis revealed challenges in knowledge translation across orthopoxviruses, including the lack of functional antigen nomenclature.
  • The antibody landscape analysis highlighted aggregate molecular properties, cross-binding/neutralization profiles, immunodominance/escape, and coverage gaps.

Conclusions:

  • Pox-AbDab facilitates research on orthopoxvirus-binding antibodies.
  • Standardization and analysis of antibody data are essential for advancing therapeutic development.
  • Identifying knowledge gaps in the orthopoxvirus antibody landscape will guide future research efforts.