Speech Acoustic Markers Can Detect Mild Cognitive Impairment in Parkinson's Disease
- 1Department of Neurology, Boston Medical Center, Boston, MA 02118 USA.
- 2Massachusetts Institute of Technology Lincoln Laboratories, Lexington, MA 02421 USA.
- 3Massachusetts Institute of Technology Lincoln Laboratories, Lexington, MA 02421 USA, and also with the Speech and Hearing Bioscience and Technology Program, Harvard Medical School, Cambridge, MA 02115 USA.
- 0Department of Neurology, Boston Medical Center, Boston, MA 02118 USA.
Related Experiment Videos
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Researchers identified distinct speech acoustic features linked to mild cognitive impairment in Parkinson's disease (PD-MCI). These biomarkers, particularly from picture descriptions, show promise for developing new tools to detect and monitor PD-MCI.
Area Of Science
- Neurology
- Speech Science
- Biomarker Discovery
Background
- Speech biomarkers are established for Parkinson's disease (PD) motor symptoms.
- Biomarkers for mild cognitive impairment in PD (PD-MCI) remain understudied.
Purpose Of The Study
- Identify speech acoustic features associated with PD-MCI.
- Develop and evaluate a model to differentiate PD-MCI from cognitively normal PD (PD-NC) individuals.
Main Methods
- Analyzed speech samples from 42 PD participants classified as PD-MCI or PD-NC.
- Extracted acoustic features from reading and picture description tasks.
- Utilized Gaussian mixture models (GMMs) for classification.
Main Results
- Picture description tasks yielded more PD-MCI-associated acoustic features than reading tasks.
- A fused GMM model achieved an AUC of 0.82 for discriminating PD-MCI from PD-NC.
- Associated acoustic features involved multiple speech subsystems.
Conclusions
- PD-MCI exhibits a unique speech acoustic signature.
- These findings support the development of novel tools for PD-MCI detection and monitoring.
Related Experiment Videos
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.