Primary Cutaneous Cribriform Apocrine Carcinoma: A Case Report and Narrative Review

Area of Science:

• Dermatopathology
• Oncology
• Histology

Background:

• Primary Cutaneous Cribriform Apocrine Carcinoma (PCCAC) is a rare, low-grade malignancy.
• It typically presents as a subcutaneous nodule on the extremities in middle-aged adults.
• PCCAC is characterized by specific histopathological features and staining patterns.

Purpose of the Study:

• To present a case of PCCAC.
• To distinguish its histological attributes from other malignancies.
• To review the histopathologic differential diagnoses and staining patterns.

Main Methods:

• Histopathological assessment of a skin lesion.
• Immunohistochemical analysis including CK7, CK5/6, BER-EP4, CD117, S100, EMA, and CEA.
• Comparison with literature findings.

Main Results:

• The case presented a well-circumscribed pandermal tumor with anastomosing solid and cribriform nests.
• Immunohistochemistry showed positive expression for CK7, CK5/6, BER-EP4, CD117, S100, EMA, and CEA.
• Negative stains for CK20, GATA-3, and p63 were noted.

Conclusions:

• PCCAC has distinct histological and immunohistochemical features.
• Accurate differentiation from other conditions is crucial for patient management.
• This case aids in understanding PCCAC's diagnostic criteria.