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Related Concept Videos

Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

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The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
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Responses to Heat and Cold Stress02:45

Responses to Heat and Cold Stress

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Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
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Treating Surfaces with a Cold Atmospheric Pressure Plasma using the COST-Jet06:36

Treating Surfaces with a Cold Atmospheric Pressure Plasma using the COST-Jet

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This protocol is presented to characterize the setup, handling, and application of the COST-Jet for the treatment of diverse surfaces such as solids and...
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Inflammatory Response01:28

Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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Generating Homo- and Heterografts Between Watermelon and Bottle Gourd for the Study of Cold-responsive MicroRNAs07:22

Generating Homo- and Heterografts Between Watermelon and Bottle Gourd for the Study of Cold-responsive MicroRNAs

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Here we present a detailed protocol for efficiently making homo- and heterografts between watermelon and bottle gourd, in addition to methods of tissue sampling, data generation, and data analysis, for the investigation of cold-responsive...
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A Thermoplasmonic Approach for Investigating Plasma Membrane Repair in Living Cells and Model Membranes06:32

A Thermoplasmonic Approach for Investigating Plasma Membrane Repair in Living Cells and Model Membranes

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The thermoplasmonic puncture method integrates confocal microscopy, optical tweezers, and gold nanoparticles to study protein responses during plasma membrane repair in cells and giant unilamellar vesicles. The technique enables rapid and localized membrane puncture, allowing the identification of key proteins and their functional roles in the intricate plasma membrane repair...
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Related Experiment Video

Updated: Jan 20, 2026

Inflammatory Response II: Inflammatory Exudate and Tissue Repair
01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

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Cold Plasma Generates a Localized Inflammatory Response and Promotes Muscle Repair.

Carly J Smith1, Amanda R Watkins2, Abigail A Lucas1

  • 1Department of Orthopedic Surgery Research, Thomas Jefferson University, 1015 Walnut Street Suite 501, Philadelphia, PA 19107, USA.

Advanced Therapeutics
|January 19, 2026
PubMed
Summary
This summary is machine-generated.

Cold plasma treatment, using the Renuvion device, enhances tissue healing by reducing inflammation and promoting muscle regeneration. This single treatment improves muscle fiber repair and reduces fat tissue formation long-term.

Keywords:
cold plasmamusclesorthopedic surgeryreactive speciestissue regeneration

More Related Videos

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Related Experiment Videos

Last Updated: Jan 20, 2026

Inflammatory Response II: Inflammatory Exudate and Tissue Repair
01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

7.5K
Treating Surfaces with a Cold Atmospheric Pressure Plasma using the COST-Jet
06:36

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Published on: November 2, 2020

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Plant Responses to Heat and Cold Stress
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Area of Science:

  • Regenerative Medicine
  • Plasma Physics
  • Molecular Biology

Background:

  • The Renuvion device, an FDA-approved cold plasma tool, is used for skin tightening.
  • Anecdotal evidence suggests improved tissue healing post-treatment.
  • Reactive species from plasma may explain healing benefits via cellular pathways.

Purpose of the Study:

  • To investigate the molecular effects of cold plasma on surgically injured muscle and soft tissue.
  • To determine immediate and long-term changes following a single plasma treatment.

Main Methods:

  • RNA sequencing to analyze gene expression changes.
  • Histology and immunohistochemistry to assess tissue structure and cellular markers.
  • Evaluation of tissue at 6 hours, 4 days, and 14 days post-treatment.

Main Results:

  • Rapid mobilization of neutrophils and mast cells at 6 hours post-treatment.
  • Upregulation of cellular antioxidant responses and pro-regenerative muscle gene transcripts.
  • Downregulation of apoptotic pathways in muscle tissue.
  • Histology and RNAseq indicate a shift towards myogenic differentiation over adipogenesis at 4 and 14 days.

Conclusions:

  • A single cold plasma treatment triggers an immediate inflammatory and antioxidant response.
  • This response promotes long-term muscle fiber repair by reducing adipogenesis.
  • Cold plasma therapy shows potential for enhancing surgical recovery and tissue regeneration.