Related Experiment Video

Updated: Jan 20, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
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Resolution of Fetal Arrhythmia Following Maternal Discontinuation of Doxylamine (Unisom): A Case Report and Review

Olivia L Ponton1, Ravi Ashwath2, Govinda Paudel2

  • 1Pediatric Cardiology, CHRISTUS Children's Hospital, San Antonio, USA.

Cureus
|January 19, 2026
PubMed

We report a case of a 36-year-old pregnant woman whose fetus exhibited frequent premature ventricular contractions (PVCs) and occasional probable premature atrial contractions (PACs) at 23 weeks' gestation. The patient was taking Unisom for nausea. After discontinuing the medication, the fetal arrhythmias resolved within a week. Postnatal evaluation showed a normal ECG, a normal QT interval, and no recurrence of arrhythmias. This case highlights the importance of thoroughly reviewing maternal medications when assessing fetal arrhythmia and suggests a possible proarrhythmic effect of doxylamine during pregnancy.

Keywords:
antihistaminesdoxylaminefetal arrhythmiapregnancypremature ventricular contraction (pvc)

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