Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Combined SPECT and CT Imaging to Visualize Cardiac Functionality09:08

Combined SPECT and CT Imaging to Visualize Cardiac Functionality

11.8K
Source: Alycia G. Berman, James A. Schaber, and Craig J. Goergen, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana
Here we will demonstrate the fundamentals of single-photon emission computed tomography/computed tomography (SPECT/CT) imaging using mice. The technique involves injecting a radionuclide into a mouse, imaging the animal after it is distributed throughout the body, and then reconstructing the produced images to create a volumetric dataset. This can...
11.8K
A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods09:49

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

10.4K
This method estimates the absorbed dose of different structures for peptide-receptor-radionuclide-therapy (PRRT) with the possibility of avoiding organ overlap on 2D-projections. Serial whole-body planar images permit estimation of mean absorbed doses along the whole body, while the hybrid approach, combining planar images and 3D-SPECT/CT image, overcomes the limitations of structure...
10.4K
Visualization of Low-Level Gamma Radiation Sources Using a Low-Cost, High-Sensitivity, Omnidirectional Compton Camera06:28

Visualization of Low-Level Gamma Radiation Sources Using a Low-Cost, High-Sensitivity, Omnidirectional Compton Camera

13.2K
We present experimental protocols for visualizing various low-level gamma radiation sources in the ambient environment using a low-cost, high-sensitivity, omnidirectional, gamma-ray imaging Compton...
13.2K
Automated Charting of the Visual Space of Housefly Compound Eyes08:34

Automated Charting of the Visual Space of Housefly Compound Eyes

2.3K
The protocol here describes the measurement of the spatial organization of the visual axes of housefly eyes, mapped by an automatic device, using the pseudopupil phenomenon and the pupil mechanism of the photoreceptor...
2.3K
Hyperspectral Imaging as a Tool to Study Optical Anisotropy in Lanthanide-Based Molecular Single Crystals07:24

Hyperspectral Imaging as a Tool to Study Optical Anisotropy in Lanthanide-Based Molecular Single Crystals

18.5K
Here, we present a protocol to obtain luminescent hyperspectral imaging data and to analyze optical anisotropy features of lanthanide-based single crystals using a Hyperspectral Imaging...
18.5K
Evaluating the Neuroprotective Effects of a Test Compound Against Alpha-Synuclein Toxicity in Rat Embryonic Neurons01:37

Evaluating the Neuroprotective Effects of a Test Compound Against Alpha-Synuclein Toxicity in Rat Embryonic Neurons

133
Start with a primary midbrain culture from rat embryos, containing dopaminergic neurons that overexpress mutated alpha-synuclein.Replace the media in the treatment wells with fresh media containing the test compound, and that in the control wells with plain media. Then incubate.In the control, alpha-synuclein forms toxic aggregates in dopaminergic neurons, causing neurite retraction and leading to neuronal death.In the treatment, the test compound interacts with alpha-synuclein, prevents its...
133

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

METTL3 suppresses pyroptosis in obstructive sleep apnea-associated hypertension via YTHDF2-mediated SOX4 mRNA degradation.

Journal of physiology and biochemistry·2026
Same author

Photoprotective Effects of <i>Dendrobium officinale</i> Protein Hydrolysate Fractions Against UVB-Induced Photoaging Associated with Modulation of MAPK/NF-κB and TGF-β/Smad Signaling.

Molecules (Basel, Switzerland)·2026
Same author

USP25 Promotes Glycolysis of Acute Myeloid Leukemia Cells and Enhances Tumor Immunity.

Archivum immunologiae et therapiae experimentalis·2026
Same author

A palladium-catalyzed three-component tandem reaction of thioamides, arenediazonium tetrafluoroborates and DABSO: an efficient synthesis of arylsulfonyl 1,3-benzothiazines.

Chemical communications (Cambridge, England)·2026
Same author

Light-Induced Proton Transfer Tautomeric Frustrated Lewis Pairs on Carbon Nitride.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Discovery of novel xanthine oxidase inhibitors using deep learning-based composite molecular fingerprint: Screening, bioactivity assessment and binding behavior analysis.

Bioorganic chemistry·2026
Same journal

Impact of DOI Capability on Detector Performance: A Comparative Study of DOI and Non-DOI Detectors for High-Resolution and Sensitivity Organ-Specific PET Inserts.

IEEE transactions on radiation and plasma medical sciences·2026
Same journal

Evaluation of a PET Insert for Trimodal Imaging: A Step Toward PET/MRI-Guided Focused Ultrasound.

IEEE transactions on radiation and plasma medical sciences·2026
Same journal

CHEMONO: a Cherenkov-Only Monolithic Detector for PGI in Proton Range Verification.

IEEE transactions on radiation and plasma medical sciences·2026
Same journal

A Virtual Clinical Trial to Detect Changes in Tumor Uptake with PET using Lesion Embedding.

IEEE transactions on radiation and plasma medical sciences·2026
Same journal

Quantitative evaluation of spatially-variant deformations recovered by deep learning on clinical-like breast lesions.

IEEE transactions on radiation and plasma medical sciences·2026
Same journal

Impact of detector parameters and image resolution modeling on dedicated brain PET imaging.

IEEE transactions on radiation and plasma medical sciences·2026
See all related articles

Related Experiment Video

Updated: Jan 20, 2026

Combined SPECT and CT Imaging for Cardiac Functionality
09:08

Combined SPECT and CT Imaging for Cardiac Functionality

Published on: April 30, 2023

11.8K

The Alpha-SPECT-Mini: A Small-Animal SPECT System based on Hyperspectral Compound-Eye Gamma Cameras.

Elena Maria Zannoni1, Can Yang2, Ling Cai2

  • 1Walker Department of Mechanical Engineering at the University of Texas at Austin, Austin, TX 78712 USA and the work described was performed when she was at the Department of Nuclear, Plasma and Radiological Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801 USA.

IEEE Transactions on Radiation and Plasma Medical Sciences
|January 19, 2026
PubMed
Summary
This summary is machine-generated.

The Alpha-SPECT-Mini system provides ultrahigh energy resolution for small animal imaging. This advanced Single Photon Emission Computed Tomography (SPECT) system enables precise imaging of alpha-emitters for preclinical research.

More Related Videos

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
09:49

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

10.4K
Visualization of Low-Level Gamma Radiation Sources Using a Low-Cost, High-Sensitivity, Omnidirectional Compton Camera
06:28

Visualization of Low-Level Gamma Radiation Sources Using a Low-Cost, High-Sensitivity, Omnidirectional Compton Camera

Published on: January 30, 2020

13.2K

Related Experiment Videos

Last Updated: Jan 20, 2026

Combined SPECT and CT Imaging for Cardiac Functionality
09:08

Combined SPECT and CT Imaging for Cardiac Functionality

Published on: April 30, 2023

11.8K
A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
09:49

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

10.4K
Visualization of Low-Level Gamma Radiation Sources Using a Low-Cost, High-Sensitivity, Omnidirectional Compton Camera
06:28

Visualization of Low-Level Gamma Radiation Sources Using a Low-Cost, High-Sensitivity, Omnidirectional Compton Camera

Published on: January 30, 2020

13.2K

Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Radiochemistry

Background:

  • Growing demand for enhanced energy resolution in Single Photon Emission Computed Tomography (SPECT) systems.
  • Need for multi-functional molecular imaging, including alpha-emitter radiopharmaceutical therapy (α-RPT).

Purpose of the Study:

  • To design and evaluate the Alpha-SPECT-Mini system for small animal studies.
  • To achieve ultrahigh energy resolution and high sensitivity for imaging alpha-emitters.

Main Methods:

  • Utilized small-pixel Cadmium Telluride (CdTe) detectors for superior energy resolution.
  • Employed a 96-collimator hole system and six stationary detection panels in a full ring configuration.
  • Validated system performance using Tc-99m and Ac-225 filled phantoms for resolution and image quality assessment.

Main Results:

  • Achieved sub-1keV Full-Width-Half-Maximum (FWHM) energy resolution for single pixel events.
  • Demonstrated average energy resolutions of ~2.5keV at 122 keV and ~3.5keV at 218 keV across 153600 pixels.
  • Successfully identified X- and gamma-ray contributions in complex spectra, crucial for Ac-225 decay chain analysis.

Conclusions:

  • The Alpha-SPECT-Mini system exhibits high performance for imaging alpha-emitters in preclinical settings.
  • The system's ultrahigh energy resolution facilitates advanced molecular imaging applications.
  • Experimental validation confirms the system's capability for preclinical alpha-emitter imaging.