Impacts of sufentanil/remifentanil plus sevoflurane versus propofol in adults undergoing laparoscopic herniorrhaphy

To retrospectively explore how sevoflurane + sufentanil/remifentanil versus propofol + sufentanil/remifentanil impacts clinical outcomes in laparoscopic herniorrhaphy-treated adults.

We enrolled 102 adult patients grouped into propofol (n=50) and sevoflurane (n=52) groups. Inter-group comparisons were made regarding operative duration, time to induction, extubation, emergence, and consciousness recovery, agitation incidence, first ambulation time, length of stay, and gastrointestinal recovery. Adverse events, hemodynamic parameters, as well as preoperative and postoperative stress markers, inflammatory cytokines, and pain mediators, were also discussed.

The sevoflurane group had statistically shorter times to extubation, consciousness recovery, first ambulation, and gastrointestinal restoration, along with lower agitation and overall adverse event rates. Shorter anesthesia emergence time and more stable hemodynamic parameters were also found in patients receiving sevoflurane compared to the propofol cohort. Better performance in postoperative stress response, inflammatory markers, and pain mediators (except for a milder decrease in β-endorphin [β-EP]) was also determined in sevoflurane-treated patients. No notable intergroup differences were identified in the durations of surgery, induction, and hospitalization.

Compared to the propofol combination, the sevoflurane-sufentanil/remifentanil regimen applied to adult laparoscopic hernia repair patients contributed to superior clinical outcomes.