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Metals as mutagens.

C P Flessel

    Advances in Experimental Medicine and Biology
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Numerous metals, including arsenic, chromium, and copper, demonstrate mutagenic properties in bacteria and can cause genetic damage in animal and plant cells. Some metal compounds may also interfere with DNA repair mechanisms, impacting genetic stability.

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    Area of Science:

    • Environmental toxicology
    • Genetics
    • Molecular biology

    Background:

    • Certain metals are known to exhibit mutagenic effects.
    • Previous studies have indicated genotoxicity of various metal compounds across different organisms.

    Purpose of the Study:

    • To review and synthesize evidence on the mutagenicity of metals.
    • To highlight metals that induce genetic damage in prokaryotic and eukaryotic systems.
    • To explore the potential impact of metals on DNA repair fidelity.

    Main Methods:

    • Literature review of studies investigating metal-induced mutagenicity.
    • Compilation of data on metals causing bacterial mutations.
    • Summary of findings on metals inducing chromosomal aberrations in animal and plant cells.

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  • Analysis of genetic evidence related to metal effects on DNA repair.

    • Main Results:

    • Arsenic, chromium, copper, iron, manganese, molybdenum, platinum, and selenium compounds are mutagenic in bacteria or phage.
    • Aluminum, antimony, arsenic, cadmium, copper, lead, mercury, nickel, and tellurium compounds induce chromosomal aberrations or abnormal cell divisions.
    • Genetic evidence implicates arsenic, chromium, and molybdenum in affecting DNA repair accuracy in microorganisms.

    Conclusions:

    • A wide range of metals possess mutagenic and genotoxic potential.
    • Metals can induce various forms of genetic damage, from point mutations to chromosomal aberrations.
    • Specific metals may disrupt fundamental cellular processes like DNA repair, with implications for genetic stability and health.