[BMim]OH Functionalized Ionic Liquid-Mediated Construction of Ferrocenyl β‑Ketosulfone Derivatives

The first 1-butyl-3-methylimidazole hydroxide ([BMim]-OH) functionalized ionic liquid-mediated catalytic strategy was proposed for the construction of ferrocenyl β-ketosulfone derivatives. A series of novel ferrocenyl derivatives were synthesized by a facile one-step reaction of chloroacetylferrocene with sodium sulfinates in dichloromethane (DCM) under air and mild conditions. All these synthesized ferrocenyl derivatives were comprehensively characterized using NMR (¹H and ¹³C) spectroscopy as well as HRMS techniques. Compounds 3a, 3d, and 3f were further confirmed using single crystal X-ray diffraction analysis. This catalytic approach provided a straightforward and effective synthetic strategy for the assembly of structurally diverse ferrocenyl β-ketosulfones with high step-economy and exceptional functional group tolerance. The results could facilitate the functionalized application of developing new ferrocenyl β-ketosulfone derivatives.