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Updated: Jan 20, 2026

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma
Published on: April 16, 2019
Structure-Guided Discovery of CHI3L1 Inhibitors from Ultralarge Chemical Spaces for Glioblastoma Therapy
Baljit Kaur1, François Sindt2, Longfei Zhang1
1Department of Radiology, Molecular Imaging Innovations Institute (MI3), Weill Cornell Medicine, New York, New York 10065, United States.
Abstract:
Glioblastoma (GBM) is a lethal brain tumor with few therapies. Targeting Chitinase 3-like 1 (CHI3L1), we used our SpaceDock structure-based virtual screen of 377 billion compounds, synthesized 60 top hits, and validated nine binders. Lead compound 9e (K d = 19.11 μM) reduced viability and STAT3 signaling in 3D GBM spheroids. These findings demonstrate the potential of reactivity-aware ultralarge screening to identify modulators of nonenzymatic, dynamic targets in complex cancer models.
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