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Updated: Jan 20, 2026

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Published on: March 13, 2018
Progressive Metastatic Cutaneous TFCP2::FUS Fusion-Positive Rhabdomyosarcoma: A Case Report.
Dustine Reich1, Fabrizio Remotti2, Esperanza Villanueva-Siles3
1Weill Cornell Medicine, New York, NY, USA.
This rare case of aggressive rhabdomyosarcoma (RMS) with a TFCP2::FUS gene fusion presented with multiple skin lesions and visceral metastases. The cancer showed resistance to multiple treatments, including chemotherapy, immunotherapy, and radiation.
Area of Science:
- Oncology
- Genetics
- Dermatology
Background:
- Rhabdomyosarcoma (RMS) is a rare soft tissue sarcoma.
- The TFCP2::FUS gene fusion is an uncommon genetic alteration in RMS.
- Multiple cutaneous lesions are an infrequent presentation of RMS.
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