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Updated: Jan 20, 2026
Oral Health Assessment by Lay Personnel for Older Adults
Published on: February 2, 2020
Oral microbiota in cardiovascular health and disease
Yi-Chuan Wu1, Bo-Yan Chen1, Sheng-Zhong Duan1
1Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, China.
Insights
The oral microbiome is linked to cardiovascular disease (CVD), but research is inconsistent. More controlled studies are needed to understand the mechanisms connecting oral bacteria and heart health.
Area of Science:
- Microbiology
- Cardiology
- Public Health
Background:
- The oral cavity hosts numerous microbes crucial for health.
- Cardiovascular disease (CVD) is a major global health concern with incompletely understood causes.
- Emerging evidence suggests a link between the oral microbiome and CVD.
Purpose of the Study:
- To review current research on mechanisms linking the oral microbiome to CVD.
- To identify gaps in understanding the interactions between oral pathogens and the cardiovascular system.
- To emphasize the need for robust population-based studies.
Main Methods:
- Comprehensive review of basic and clinical research.
- Analysis of existing human and animal studies.
- Identification of mechanistic pathways.
Main Results:
- Inconsistent findings in human studies due to variations in populations, follow-up, and disease severity.
- Animal studies explored individual species but left mechanistic gaps.
- A complete understanding of oral pathogen-cardiovascular system interactions is lacking.
Conclusions:
- The relationship between the oral microbiome and CVD requires further investigation.
- Standardized, population-based studies are essential to establish causal links.
- Elucidating these mechanisms is critical for public health.
Abstract:
Hundreds of microbial species inhabit the oral cavity and are essential to local and systemic health. Cardiovascular disease (CVD) causes a significant burden on global health, with its etiology and pathogenesis still not fully understood. Growing evidence indicates an association between the oral microbiome and CVD. However, the variability of populations, follow-up durations, and disease severity between various human investigations led to divergent conclusions. Animal studies have focused on the relationship between individual microbial species and CVD, yet gaps remain in the mechanisms between CVD and microbiome. In addition, a comprehensive understanding of the interactions between oral pathogens and the cardiovascular system has not been elucidated. In this Review, we summarize our current knowledge of basic and clinical research on potential mechanisms linking the oral microbiome to CVD and highlight the need for population-based studies with controlled baselines to establish mechanism links between oral microbial pathways and CVD.
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