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Updated: Jan 20, 2026

Author Spotlight: High-Quality Quantum Dot Nanobeads for Sensitive Fluorescent Lateral Flow Immunoassays
Published on: June 28, 2024
Fluorescent biosensor based cerium-doped carbon quantum dots for albumin detection
Nashwa Ashraf Hafez1, Eman Fadl1, Shaker Ebrahim1
1Department of Materials Science, Institute of Graduate Studies and Research, Alexandria University P.O. Box 832 Alexandria Egypt azzashokry@alexu.edu.eg.
Abstract:
Accurate detection of albumin proteins is crucial for diagnosing different diseases. A fluorescent sensor has been developed using cerium (Ce) doped carbon quantum dots (CQDs) to detect bovine serum albumin (BSA) in blood and urine samples. Pristine CQDs and Ce-CQDs were synthesized through citric acid pyrolysis. CQDs and Ce-CQDs exhibited emission peaks at 415 nm and 426 nm, respectively. Based on the photoluminescence (PL) enhancement of Ce-CQDs resulting from adding BSA, BSA was quantified within two minutes. This biosensor was selective and sensitive towards BSA in the concentrations ranging from 1 to 1000 µM with a high correlation coefficient and a low detection limit of 0.98 µM (6.5 × 10-2 g L-1), which meets the requirement well for clinical analysis. The practical usefulness of Ce-CQDs as a fluorescent biosensor was confirmed by accurately quantifying BSA in human serum and urine samples with satisfactory recovery percentages.
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