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Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
Published on: January 7, 2019
12-Step Participation Is Linked to Lower Drinking and Specific Impulsive Personality Traits in Early Alcohol Use
Emily E Levitt1, Kyla L Belisario2, Amanda Doggett2
1Youth Wellness Centre, St. Joseph's Healthcare, Hamilton, Ontario, Canada.
Increased attendance in 12-step groups (TS) for alcohol use disorder (AUD) reduced drinking and some impulsivity traits. However, impulsivity did not mediate the positive effects of TS on alcohol recovery.
Area of Science:
- Addiction research
- Clinical psychology
- Neuroscience
Background:
- 12-step facilitation (TS) is a common intervention for alcohol use disorder (AUD).
- Reduced impulsivity is a proposed mechanism for TS benefits in AUD recovery.
- Multidimensional impulsivity assessment is crucial for understanding AUD treatment effects.
Purpose of the Study:
- To examine the longitudinal impact of increased TS attendance on impulsivity and drinking in adults with AUD.
- To investigate whether impulsivity mediates the relationship between TS attendance and alcohol outcomes.
Main Methods:
- Prospective matched-sample cohort study comparing increased TS attendance (≥1 meeting/week) versus no increase.
- Assessment of drinking (% drinking days, % heavy drinking days) and impulsivity (delay discounting, UPPS-P subscales).
- Mediation models to test the role of impulsivity in the TS-alcohol outcome relationship.
Main Results:
- Increased TS attendance was linked to significant reductions in drinking (%DD, %HDD).
- Participants with increased TS attendance also showed reductions in Negative Urgency and Lack of Perseverance.
- Impulsivity measures did not mediate the association between increased TS attendance and reduced drinking.
Conclusions:
- Increased TS attendance is associated with improved drinking behavior and specific impulsivity traits during early AUD recovery.
- Impulsivity does not appear to be the primary mechanism driving the benefits of TS for AUD.
- Further research with larger samples and longer follow-up is needed to clarify the role of impulsivity in TS effectiveness.
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