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Related Experiment Video

Updated: Jan 20, 2026

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
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Ocular Imaging in Intraocular Lymphoma: A Review.

Amin Ibrahim1, Vishal B Swaminathan1, Wendy M Smith1

  • 1Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA.

Clinical & Experimental Ophthalmology
|January 19, 2026
PubMed
Summary
This summary is machine-generated.

Multimodal imaging can help detect rare intraocular lymphomas, like vitreoretinal and choroidal lymphoma, by identifying characteristic features. Early detection through imaging aids timely referrals and accurate diagnosis of these eye cancers.

Keywords:
biomarkersintraocular lymphomamultimodal imaging

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Oncology

Background:

  • Intraocular lymphomas (vitreoretinal, choroidal) mimic other ocular diseases, causing diagnostic delays.
  • Early clinical suspicion through imaging is crucial for timely referrals and treatment.

Purpose of the Study:

  • To review the diagnostic and prognostic value of multimodal imaging features in intraocular lymphomas.
  • To highlight discriminative biomarkers for vitreoretinal or choroidal lymphoma and differentiate from other diagnoses.

Main Methods:

  • Systematic review of current evidence on imaging modalities.
  • Analysis of findings from fundus photography, OCT, FAF, FA, ICG, OCTA, and ultrasound.
  • Focus on characteristic imaging biomarkers and longitudinal changes.

Main Results:

  • Specific multimodal imaging features can raise suspicion for intraocular lymphomas.
  • Key findings help differentiate lymphoma from benign or other malignant conditions.
  • Longitudinal imaging changes assist in tracking disease progression and treatment response.

Conclusions:

  • Multimodal imaging plays a vital role in the early diagnosis of intraocular lymphomas.
  • Consolidated imaging findings facilitate accurate diagnosis and appropriate patient management.
  • This review provides a comprehensive guide for identifying these rare ocular malignancies.