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Updated: Jan 20, 2026

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Published on: March 31, 2023

Multiple orthokeratinized odontogenic cysts - A case report.

Giri Prarthana¹, Veeran Veeravarmal¹, Ramdas M Nirmal¹

¹Department of Oral and Maxillofacial Pathology and Oral Microbiology, Government Dental College and Hospital, Chidambaram, Tamil Nadu, India.

Indian Journal of Pathology & Microbiology

|January 19, 2026

Summary

Multiple orthokeratinized odontogenic cysts (OOC) were diagnosed in a patient with a history of a similar lesion. This case highlights OOC as a distinct entity from Odontogenic keratocyst (OKC).

Keywords:

Multiple orthokeratinized odontogenic cysts odontogenic keratocyst unilocular radiolucency

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Published on: December 2, 2014

Area of Science:

Oral and Maxillofacial Surgery
Oral Pathology
Dentistry

Background:

Orthokeratinized odontogenic cysts (OOC) are rare developmental jaw cysts.
Previously classified as an orthokeratinized variant of Odontogenic keratocyst (OKC).
OOC exhibits distinct clinical and histological characteristics compared to OKC.

Purpose of the Study:

To report a case of multiple OOC.
To emphasize the diagnostic criteria differentiating OOC from OKC.
To discuss the clinical significance of multiple OOC occurrences.

Main Methods:

Radiographic evaluation of jaw lesions.
Histopathological examination of cyst epithelium and contents.
Clinical assessment of patient history and presentation.

Main Results:

A 34-year-old male presented with multiple radiolucent jaw lesions.
Histopathology revealed thin, uniform orthokeratinized stratified squamous epithelium with intraluminal keratin in both lesions.
The lesions were diagnosed as multiple OOC, distinct from the patient's prior OKC diagnosis.

Conclusions:

Multiple OOC can occur in the jaws.
Accurate histopathological diagnosis is crucial for differentiating OOC from OKC.
OOC represents a distinct clinicopathological entity within odontogenic cysts.