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Updated: Jan 20, 2026

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding
Published on: August 30, 2024
Valvular and Outflow Tract Metastases From Germ Cell Tumors: Contrasting Left-Sided Embolism and Right-Sided Silence
Enrique Ruiz-Mori1, Alfonso Gonzalez-Trejo2, Ana K Nieto-Dolores3
1Department of Cardiology, National Institute of Neoplastic Diseases, Lima, Peru; Department of Cardio-oncology, National Institute of Neoplastic Diseases, Lima, Peru; San Martin Porres University, Santa Anita, Peru.
Background:
Nonseminomatous testicular germ cell tumors (TGCTs) rarely metastasize to the heart, posing cardiovascular diagnostic and management challenges.
Case Summary:
We present 2 young men (20 and 28 years) with advanced mixed TGCTs. One developed acute ischemic stroke and myocardial infarction, the other a multifocal murmur. Both showed elevated alpha-fetoprotein, beta human chorionic gonadotropin, and pulmonary nodules. Transthoracic echocardiography revealed atrioventricular valves and outflow tract masses.
Discussion:
In TGCT, embolic or new cardiovascular findings should prompt urgent transthoracic echocardiography to assess cardiac metastases. Early multimodality imaging can uncover silent disease and guide timely multidisciplinary care. Management focuses on definitive tumor resection and platinum-based chemotherapy.
Take-Home Messages:
Cardiac metastases from testicular cancer may first present with neurological or cardiovascular symptoms. Right-sided secondary cardiac tumors may be silent, whereas left-sided involvement may cause embolic events.
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