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Dementia in Progressive Supranuclear Palsy: A Narrative Review.

Kathleen S Moore1, Yara S Stipho2, Nicki Niemann3

  • 1Creighton University School of Medicine-Phoenix, Phoenix, AZ, USA.

Neurology and Therapy
|January 19, 2026
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Progressive supranuclear palsy (PSP) is a neurodegenerative disease impacting motor skills and cognition due to tau protein buildup. This review details PSP dementia, its diagnosis, and clinical features.

Keywords:
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Area of Science:

  • Neuroscience
  • Neurology

Background:

  • Progressive supranuclear palsy (PSP) is an adult-onset neurodegenerative disorder.
  • It is characterized by postural instability, ocular motor dysfunction, akinesia, and cognitive impairment.
  • Tau protein accumulation disrupts microtubule dynamics and axonal transport, causing neurodegeneration.

Purpose of the Study:

  • To describe cognitive decline and dementia in PSP.
  • To provide context for diagnosing PSP dementia.
  • To discuss pathological hallmarks, clinical features, and diagnostic criteria of PSP.

Main Methods:

  • This is a narrative review.
  • Literature search on PSP, cognitive decline, dementia, tau pathology, and diagnostic criteria.

Main Results:

  • Cognitive impairment and dementia are common in PSP.
  • Diagnosis of dementia in PSP can be challenging.
  • PSP dementia shares pathological hallmarks with PSP.

Conclusions:

  • Understanding PSP dementia requires knowledge of its pathological hallmarks, clinical features, and diagnostic criteria.
  • This review provides a comprehensive overview for diagnosing PSP dementia.
  • Further research may improve early diagnosis and management of PSP dementia.