Dementia in Progressive Supranuclear Palsy: A Narrative Review

Area of Science:

• Neuroscience
• Neurology

Background:

• Progressive supranuclear palsy (PSP) is an adult-onset neurodegenerative disorder.
• It is characterized by postural instability, ocular motor dysfunction, akinesia, and cognitive impairment.
• Tau protein accumulation disrupts microtubule dynamics and axonal transport, causing neurodegeneration.

Purpose of the Study:

• To describe cognitive decline and dementia in PSP.
• To provide context for diagnosing PSP dementia.
• To discuss pathological hallmarks, clinical features, and diagnostic criteria of PSP.

Main Methods:

• This is a narrative review.
• Literature search on PSP, cognitive decline, dementia, tau pathology, and diagnostic criteria.

Main Results:

• Cognitive impairment and dementia are common in PSP.
• Diagnosis of dementia in PSP can be challenging.
• PSP dementia shares pathological hallmarks with PSP.

Conclusions:

• Understanding PSP dementia requires knowledge of its pathological hallmarks, clinical features, and diagnostic criteria.
• This review provides a comprehensive overview for diagnosing PSP dementia.
• Further research may improve early diagnosis and management of PSP dementia.