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Updated: Jan 20, 2026

MRI and PET in Mouse Models of Myocardial Infarction
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Beyond Parkinsonism: 18 F-FDOPA Brain PET/MRI for Detection of High-grade Glioma

Michelle Chen1, Martin Niethammer2, Ana M Franceschi1

  • 1Department of Radiology, Neuroradiology Division, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Lenox Hill Hospital, New York, NY.

Clinical Nuclear Medicine
|January 19, 2026
PubMed

Insights

A patient with parkinsonism symptoms was diagnosed with glioblastoma using 18F-FDOPA PET/MRI. This imaging technique revealed an unexpected tumor in the brain

Area of Science:

  • Neuroimaging
  • Neurology
  • Oncology

Background:

  • A 72-year-old male presented with parkinsonian symptoms, but clinical presentation was atypical for degenerative parkinsonism.
  • Initial MRI revealed splenium T2/FLAIR hyperintensity, initially presumed to be small vessel disease.

Purpose of the Study:

  • To investigate the cause of atypical parkinsonism and splenium abnormalities.
  • To evaluate the utility of 18F-FDOPA PET/MRI in differentiating parkinsonism and assessing brain lesions.

Main Methods:

  • Performed 18F-FDOPA brain PET/MRI to assess for degenerative parkinsonism.
  • Utilized contrast-enhanced MRI to further characterize the splenium lesion.
  • Conducted stereotactic biopsy for histopathological confirmation.

Main Results:

  • 18F-FDOPA PET/MRI excluded degenerative parkinsonism and showed high tracer uptake in the splenium (SUVmax 4.46).
  • Contrast-enhanced MRI identified a peripherally enhancing splenium lesion suggestive of neoplasm.
  • Biopsy confirmed diffuse high-grade glioblastoma, IDH-wildtype, WHO Grade 4.

Conclusions:

  • 18F-FDOPA PET/MRI can be crucial in diagnosing primary brain tumors presenting with atypical neurological symptoms.
  • This case highlights the value of 18F-FDOPA PET in identifying and characterizing brain neoplasms.
Keywords:
Brain PETHigh-Grade GliomaIDH-wildtypePET/MRI

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