Comparative phospholipid profiling of human milk and infant formulas using LC-MS/MS and a multi-parameter similarity
Huiquan Zhu1, Marie-Laure Fauconnier2, Hong Zhang3
1Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China; Laboratory of Chemistry of Natural Molecules, Gembloux Agro-bio Tech, University of Liege, Gembloux 5030, Belgium.
None:
Human milk phospholipid (HMPL) plays an indispensable role in infant growth, while there are few studies focused on the comprehensive phospholipid composition between human milk and infant formula. In this study, LC-MS/MS and a similarity evaluation model were used to compare phospholipid composition from human milk and infant formula. The results showed that the number of phospholipid molecules detected in HM (137) was higher than that in CIFs (86) and GIFs (77). Furthermore, the similarity evaluation showed that although the average comprehensive similarity score for CIFs (65.68) was higher than that for GIFs (53.62), their phospholipid compositions differed significantly from HMPLs. Therefore, these results not only deepen our understanding of HM phospholipids but also provide a new scientific basis for the development of infant formulas.
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