Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

262
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
262
Theory of Romantic Attachment in Adulthood03:34

Theory of Romantic Attachment in Adulthood

48.6K
Attachment is a long-standing connection or bond with others. While Attachment Theory was conceived in developmental psychology to describe infant-caregiver bonding, it's been extended into adulthood to include romantic relationships. 
48.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Procedural options in the prescription of outpatient intensive care and potential assessment in children and adolescents.]

Klinische Padiatrie·2026
Same author

Insights from a novel monogenic autoinflammatory disease: overview of a multicentric European cohort of 38 patients with COPA syndrome.

Annals of the rheumatic diseases·2025
Same author

Synthesis, Supramolecular Assembly, and Hydrogelation of Poly(amino ester) ABA Triblock Copolymers.

Biomacromolecules·2025
Same author

[Pediatric pneumological aspects in the care of children with Down Syndrome].

Klinische Padiatrie·2025
Same author

Electrochemical Chlorine Shuttle from PVC Waste to Vinyl Ether Acceptors for the Synthesis of Biodegradable Polyester Precursors.

Advanced materials (Deerfield Beach, Fla.)·2025
Same author

[Pediatric pneumological aspects in the care of children with neuromuscular diseases with focus on Duchenne muscular dystrophy].

Klinische Padiatrie·2024

Related Experiment Video

Updated: Jan 21, 2026

Author Spotlight: Marmoset Research - Scope and Challenges
04:52

Author Spotlight: Marmoset Research - Scope and Challenges

Published on: June 9, 2023

2.6K

[Infant with cyanosis and hypoxemia].

Simone Nicolaus1, Ute Friederike Jarmola2, Sebastian Becker2

  • 1Allgemeine Pädiatrie, Darmstädter Kinderkliniken Prinzessin Margaret, Darmstadt, Germany.

Klinische Padiatrie
|January 19, 2026
PubMed
Summary

Local anesthetics like mepivacaine can cause dangerous methemoglobinemia in infants. This condition, marked by abnormal skin color and hypoxemia, is treatable with methylene blue.

More Related Videos

P50 Sensory Gating in Infants
12:55

P50 Sensory Gating in Infants

Published on: December 26, 2013

9.6K
Electrophysiological Measurements and Analysis of Nociception in Human Infants
09:18

Electrophysiological Measurements and Analysis of Nociception in Human Infants

Published on: December 20, 2011

17.6K

Related Experiment Videos

Last Updated: Jan 21, 2026

Author Spotlight: Marmoset Research - Scope and Challenges
04:52

Author Spotlight: Marmoset Research - Scope and Challenges

Published on: June 9, 2023

2.6K
P50 Sensory Gating in Infants
12:55

P50 Sensory Gating in Infants

Published on: December 26, 2013

9.6K
Electrophysiological Measurements and Analysis of Nociception in Human Infants
09:18

Electrophysiological Measurements and Analysis of Nociception in Human Infants

Published on: December 20, 2011

17.6K

Area of Science:

  • Pediatric Anesthesiology
  • Toxicology
  • Hematology

Background:

  • Infants are susceptible to methemoglobinemia due to underdeveloped enzyme systems.
  • Methemoglobinemia impairs oxygen transport, leading to cyanosis and hypoxemia.

Purpose of the Study:

  • To report a case of infant methemoglobinemia following local anesthesia.
  • To highlight the risks of mepivacaine in pediatric patients.
  • To emphasize timely diagnosis and treatment of methemoglobinemia.

Main Methods:

  • Case report of an 8-week-old infant presenting with cyanosis post-achillotomy.
  • Analysis of blood gas and methemoglobin levels.
  • Treatment with methylene blue.

Main Results:

  • Elevated methemoglobin level (38%) confirmed post-mepivacaine anesthesia.
  • Infant presented with cyanosis, hypoxemia, and lactic acidosis.
  • Complete recovery (restitutio ad integrum) after methylene blue administration.

Conclusions:

  • Local anesthetics, particularly mepivacaine, can induce methemoglobinemia in infants.
  • Recognizing methemoglobinemia is crucial for prompt and effective treatment.
  • Methylene blue is an effective antidote for this condition.