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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Psychodynamic therapies emphasize the exploration of unconscious processes and early childhood experiences as fundamental contributors to psychological difficulties. These therapies, deeply rooted in Freud's psychoanalytic theory, aim to uncover and resolve unconscious conflicts, granting individuals insights that promote emotional and behavioral healing. Contemporary psychodynamic approaches have evolved, integrating a broader range of influences and methodologies while still valuing the...
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Humanistic therapies emphasize personal growth, self-understanding, and the fulfillment of human potential. Rooted in the belief that individuals inherently strive toward self-actualization, these approaches encourage clients to explore their feelings and experiences in a supportive, nonjudgmental environment. Humanistic therapies differ from psychodynamic approaches by focusing on conscious experiences, present circumstances, and the potential for self-improvement rather than past conflicts...
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Cerenkov Luminescence Imaging CLI for Cancer Therapy Monitoring
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Pollutants and cancer therapy.

Francisco Alejandro Lagunas-Rangel1

  • 1Department of Genetics and Molecular Biology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico.

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|January 19, 2026
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Environmental pollutants can reduce cancer treatment effectiveness by affecting drug action and promoting resistance. Further research is needed to understand these interactions and improve patient outcomes.

Keywords:
BPAB[a]PPFASPM(2.5)Phthalates

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Area of Science:

  • Environmental Science
  • Toxicology
  • Oncology

Background:

  • Environmental pollutants pose significant health risks, yet their impact on cancer therapy is underestimated.
  • Understanding pollutant effects on cancer treatment is crucial for public health.
  • Few studies address pollutant impacts at realistic environmental exposure levels.

Purpose of the Study:

  • To analyze cellular mechanisms by which pollutants affect cancer therapy efficacy.
  • To explore pollutant interactions with chemotherapy and immunotherapy.
  • To highlight the need for considering pollutants in cancer treatment strategies.

Main Methods:

  • This narrative review analyzes existing literature on environmental pollutants and cancer therapy.
  • It examines cellular and molecular mechanisms of pollutant-induced treatment resistance.
  • The review considers pharmacokinetic, immunomodulatory, and tumor microenvironment effects.

Main Results:

  • Pollutants can enhance drug efflux, activate oncogenic pathways, inhibit apoptosis, alter mitochondria, and downregulate tumor suppressors.
  • Pollutants may affect drug pharmacokinetics, immune responses, and the tumor microenvironment.
  • Mixtures of pollutants can synergistically increase cancer cell survival and resistance.

Conclusions:

  • Environmental pollutants can significantly compromise cancer therapy outcomes.
  • Pollutants influence multiple cellular pathways, leading to treatment resistance.
  • Increased awareness and research on pollutant-cancer interactions are essential for clinical practice.