Related Experiment Video

Updated: Jan 21, 2026

Standardization of Basket Use in Sialendoscopy: A Ten-Year Retrospective Study
09:36

Standardization of Basket Use in Sialendoscopy: A Ten-Year Retrospective Study

Published on: June 6, 2025

539

Subureteric injection in complex vesicoureteral reflux in pediatric patients: a retrospective observational study

Çiğdem Arslan Alıcı1, Baran Tokar2

  • 1Department of Pediatric Urology, University of Health Sciences Eskisehir City Hospital, Eskisehir, Turkey.

Advances in Medical Sciences
|January 19, 2026
PubMed

Insights

Subureteric injection (SUI) and ureteral reimplantation show similar success rates for treating vesicoureteral reflux (VUR) in children. SUI is a viable option, especially for older children with low-grade VUR.

Area of Science:

  • Pediatric Urology
  • Surgical Interventions
  • Vesicoureteral Reflux Management

Background:

  • Vesicoureteral reflux (VUR) is a common condition in children requiring effective treatment.
  • Surgical options for VUR include subureteric injection (SUI) and ureteral reimplantation (UR).
  • Evaluating treatment effectiveness in complex pediatric VUR cases is crucial.

Purpose of the Study:

  • To compare the effectiveness of SUI versus UR in treating pediatric VUR.
  • To determine if SUI reduces the need for repeat surgical interventions, particularly in complex VUR cases.
  • To assess the success rates of SUI and UR in different VUR grades and patient demographics.

Main Methods:

  • Retrospective analysis of 132 children with VUR, divided into simple (n=65) and complex (n=67) cases.
  • Diagnosis of VUR and complex pathologies confirmed via voiding cystourethrography (VCUG) and cystoscopic examination.
  • VUR grading followed the International Reflux Study Committee classification; treatments included SUI and intravesical ureteroneocystostomy (UNC).

Main Results:

  • Complex pathologies included duplex systems, bladder diverticulum, trabeculation, and posterior urethral valves.
  • SUI success rate was 65.6%, comparable to UR at 70.6% (p=0.68).
  • Lower success rates were observed in children aged 0-2 years with high-grade VUR (Grade 5: 45%) and renal scarring (48%).

Conclusions:

  • SUI and UR demonstrate comparable efficacy in treating both simple and complex VUR.
  • SUI presents a viable first-line surgical option for pediatric VUR, especially in patients over 2 years with low-grade reflux.
  • Further research is warranted to validate these findings and optimize treatment strategies.
Abstract

Keywords:
Bladder diverticulumPediatricSubureteric injectionVesicoureteral reflux

More Related Videos

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients03:47

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

Published on: October 25, 2024

615
Whole-body PET/MRI of Pediatric Patients: The Details That Matter10:02

Whole-body PET/MRI of Pediatric Patients: The Details That Matter

Published on: December 19, 2017

15.2K

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
214
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
261
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
196
Observational Studies01:11

Observational Studies

Observational studies are a type of analytical study where researchers observe events without any interventions. In other words, the researcher does not influence the response variable or the experiment's outcome.
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
10.7K
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
250
Naturalistic Observations02:30

Naturalistic Observations

If you want to understand how behavior occurs, one of the best ways to gain information is to simply observe the behavior in its natural context. However, people might change their behavior in unexpected ways if they know they are being observed. How do researchers obtain accurate information when people tend to hide their natural behavior? As an example, imagine that your professor asks everyone in your class to raise their hand if they always wash their hands after using the restroom. Chances...
17.0K