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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

590
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Histone Modification02:32

Histone Modification

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
16.0K
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
572
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

356
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
356
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

328
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
328
Kidney Structure01:45

Kidney Structure

75.0K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
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A Possible Zebrafish Model of Polycystic Kidney Disease: Knockdown of wnt5a Causes Cysts in Zebrafish Kidneys
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Gene modification: Exploring the potential in treating kidney diseases.

Ubong S Ekperikpe1, Serena Zhao1, Ilse S Daehn1

  • 1Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, USA.

Pharmacological Research
|January 19, 2026
PubMed
Summary
This summary is machine-generated.

Gene therapies offer a promising new avenue for treating chronic kidney disease (CKD), potentially overcoming limitations of current treatments like dialysis and transplantation. Research is exploring gene editing technologies for precision kidney disease management.

Keywords:
gene editinggene therapykidney disease

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Area of Science:

  • Nephrology
  • Genetics
  • Biotechnology

Background:

  • Chronic kidney disease (CKD) is a major global health concern with limited curative treatments.
  • Current therapies for end-stage renal disease, such as dialysis and transplantation, have significant drawbacks.
  • Genetic factors are increasingly recognized as crucial in CKD development and progression.

Purpose of the Study:

  • To review the potential of gene therapies for managing CKD.
  • To explore recent gene editing technologies, their mechanisms, and delivery strategies.
  • To discuss challenges and future perspectives for gene therapy in kidney diseases.

Main Methods:

  • Review of current literature on gene editing technologies and their application to kidney diseases.
  • Analysis of genetic and genomic insights into CKD pathophysiology.
  • Exploration of artificial intelligence and machine learning in precision gene editing.

Main Results:

  • Gene editing technologies show potential for novel CKD treatments.
  • Advances in gene delivery systems are crucial for therapeutic success.
  • AI and machine learning can enhance precision in gene editing for kidney diseases.

Conclusions:

  • Gene therapy represents a promising frontier for CKD treatment, moving beyond current palliative measures.
  • Overcoming challenges in delivery, safety, and regulatory pathways is key for clinical adoption.
  • Future research directions include precision editing and integration of AI for personalized kidney disease management.