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Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Epigenetic Regulation

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Related Experiment Video

Updated: Jan 21, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

Integrative epigenetics and transcriptomics identify aging genes in human blood.

Mahdi Moqri¹, Kejun Ying^2,3, Jesse R Poganik²

¹Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA. mmoqri@bwh.harvard.edu.

Nature Communications

|January 19, 2026

Summary

This study integrates epigenetic and transcriptomic data to identify aging genes in blood. These multi-omic aging genes are linked to immune function and aging outcomes, offering potential for cellular rejuvenation.

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Last Updated: Jan 21, 2026

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Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome

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Published on: February 24, 2023

Area of Science:

Genomics
Epigenetics
Aging Research

Background:

Epigenome-wide studies reveal age-related methylation changes, but functional impacts are unclear.
Transcriptomic aging studies show limited cross-population replication.
Integrating multi-omic data is crucial for understanding aging mechanisms.

Purpose of the Study:

To develop an integrative approach for analyzing epigenetic and transcriptomic age-related changes.
To identify genomic regions with age-dependent changes in both epigenetics and transcriptomics in blood.
To explore the functional consequences and replicability of multi-omic aging genes.

Main Methods:

Leveraged high-resolution multi-omic data (epigenetic and transcriptomic).
Performed integrative analysis of age-related changes in blood.
Identified genomic regions associated with both epigenetic and transcriptomic age-dependent changes.

Main Results:

Identified multi-omic aging genes in blood enriched for adaptive immune functions.
These genes demonstrated more robust replication across diverse populations.
Multi-omic aging genes showed stronger associations with aging-related outcomes compared to single-omic approaches.

Conclusions:

Multi-omic aging genes provide a more reliable signature of aging in blood.
These genes are functionally linked to immune processes and aging outcomes.
Multi-omic aging genes may be targets for epigenetic editing to promote cellular rejuvenation.