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Association between thyroid hormone sensitivity indices and renal function in community-dwelling euthyroid older
Junzhe Xie1, Chunlian Zhang2, Jifeng Fan2
1Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Scientific Reports
|January 19, 2026
Summary
Central thyroid hormone sensitivity indices, including TSHI and TT4RI, are linked to reduced kidney function in euthyroid older adults. These findings highlight potential connections between thyroid regulation and renal health in aging populations.
Area of Science:
- Endocrinology
- Nephrology
- Geriatrics
Background:
- Thyroid hormone sensitivity indices (TFQI, TSHI, TT4RI) assess central thyroid hormone regulation.
- The relationship between these indices and kidney function in euthyroid older adults remains unclear.
Purpose of the Study:
- To investigate the association between central thyroid hormone sensitivity indices and kidney function (eGFR) in community-dwelling euthyroid older adults.
Main Methods:
- Cross-sectional study of 2,027 euthyroid adults (≥65 years) in Shanghai.
- Calculated TFQI, TSHI, TT4RI; measured eGFR using MDRD equation.
- Used multivariate regression and restricted cubic spline analyses to examine associations.
Main Results:
- Prevalence of reduced renal function was 15.9%.
- All three indices were higher in participants with impaired renal function.
- TSHI and TT4RI showed significant inverse associations with eGFR and reduced renal function after adjustment.
Conclusions:
- Central thyroid hormone sensitivity indices, particularly TSHI and TT4RI, are independently associated with lower renal function in euthyroid older adults.
- Findings suggest a link between thyroid regulation and kidney health in the elderly.
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