Non-Invasive Break-Up Time in the Beijing Adult Dry Eye Cohort Study (ADEC): A Cross-Sectional Baseline Analysis

Area of Science:

• Ophthalmology
• Epidemiology
• Public Health

Background:

• Dry eye disease is a prevalent condition affecting a significant portion of the adult population.
• Non-Invasive Break-Up Time (NIBUT) is a crucial indicator of ocular surface stability.
• Understanding factors influencing NIBUT is essential for effective dry eye management.

Purpose of the Study:

• To investigate the distribution of Non-Invasive Break-Up Time (NIBUT) in adults residing in Beijing.
• To identify associations between NIBUT and demographic characteristics, systemic diseases, lifestyle factors, and psychological status.

Main Methods:

• A population-based, cross-sectional study was conducted using data from the Beijing Adult Dry Eye Cohort (ADEC).
• 1,087 adult participants were analyzed, with assessments including dry eye clinical signs and questionnaires.
• Statistical analyses included univariable and multivariable regression models to identify factors associated with NIBUT.

Main Results:

• The mean NIBUT was 11.84 ± 4.39 seconds.
• Younger adults, males, and individuals without myopia had significantly higher NIBUT.
• Independent predictors of lower NIBUT included female sex, older age, myopia, oral mucosal dryness, and higher depression and anxiety scores.

Conclusions:

• NIBUT is significantly associated with a combination of demographic, ocular, and psychological factors in the Beijing adult population.
• These findings underscore the need for a holistic, multi-factorial approach in diagnosing and managing dry eye disease.
• Comprehensive assessment considering these associated factors can improve clinical outcomes for dry eye patients.